Preventing catheter-associated UTIs has emerged as a priority in the United States. Catheter-associated UTI was the first hospital-acquired complication chosen by CMS in 2008 as the basis for denial of additional payment to hospitals. Since that time, more initiatives have been launched to provide strategic guidance for preventing infections in acute care hospitals. Despite these efforts, national data indicate that the incidence of catheter-associated UTI increased by 6% from 2009 to 2013. Recently, the AHRQ and several other partners launched a nationwide effort to implement the Comprehensive Unit-Based Safety Program to reduce catheter-associated UTIs in ICUs as well as non-ICUs. This effort involved an explicit focus on the technical and socioadaptive aspects of preventing catheter-associated UTIs.