The DM1 Masterclass is a virtual educational program designed for healthcare professionals involved in the diagnosis, treatment, and multidisciplinary management of patients with Myotonic Dystrophy Type 1 (DM1). As the understanding of DM1 continues to evolve, with advances in genetic diagnostics, disease monitoring, standards of care, and emerging therapeutic approaches, clinicians require access to up-to-date, evidence-based education to support optimal patient outcomes. Given the multisystem nature of DM1 and its highly variable presentation, healthcare professionals must be able to recognise the condition early and understand its lifelong impact on patients and families.

This interactive masterclass will bring together internationally recognised experts, healthcare professionals, patients, and patient advocacy representatives to provide a comprehensive overview of the current DM1 landscape. Participants will enhance their knowledge and confidence in the diagnosis and early recognition of DM1 through practical, evidence-based education on clinical presentation, diagnostic pathways, genetic testing, genotype-phenotype considerations, and the evolving understanding of disease progression. Particular attention will be given to recognising key features of DM1, including myotonia, distal and proximal muscle weakness, fatigue, excessive daytime sleepiness, cardiac conduction abnormalities, respiratory impairment, gastrointestinal dysfunction, endocrine manifestations, and cognitive and behavioural symptoms.

Through expert-led presentations and case-based discussions, attendees will strengthen their understanding of multidisciplinary management approaches in DM1. The programme will explore current standards of care and practical strategies for managing the diverse clinical manifestations of the disease across key domains, including respiratory, cardiac, gastrointestinal, musculoskeletal, cognitive, and psychological health. Participants will gain insights into the role of coordinated multidisciplinary care in improving patient outcomes and quality of life, while addressing the complex and evolving needs of individuals living with DM1.

Recognising that DM1 affects many aspects of daily living beyond physical symptoms, the masterclass will also examine the lifelong impact of the condition on patients and families. Through patient perspectives and expert discussion, participants will develop a greater appreciation of the clinical, cognitive, functional, and psychosocial challenges associated with DM1, including education, employment, independence, relationships, family planning, caregiver burden, and long-term care planning. The programme will highlight how these factors influence treatment decisions and the delivery of person-centred care throughout the patient journey.

The masterclass will also provide an overview of the current clinical trial landscape and emerging therapeutic developments in DM1, enabling participants to better understand future treatment opportunities and their potential implications for clinical practice. A dedicated clinical case studies workshop will facilitate interactive discussion of real-world challenges, encourage the sharing of experiences and best practices, and support participants in applying learning to the management of patients with DM1 in everyday clinical settings.